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Article

Fitness landscape transformation through a single amino acid change in the rho terminator.

PLoS genetics - 1 May 2012

Freddolino Peter L, Goodarzi Hani, Tavazoie Saeed

Abstract excerpt

Regulatory networks allow organisms to match adaptive behavior to the complex and dynamic contingencies of their native habitats. Upon a sudden transition to a novel environment, the mismatch between the native behavior and the new niche provides selective pressure for adaptive evolution through...

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Topics

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Share to Adaptation, Biological
Share to Amino Acid Substitution
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Transposable Elements

Share to Gene Expression Regulation, Bacterial

Share to Genetic Fitness

Share to Mutagenesis

Share to Rho Factor

Source

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Identifiers

PMID: 22693458
DOI: 10.1371/journal.pgen.1002744
PMCID: PMC3364947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22693458-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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