Polymorphism in the Drug Transporter Gene ABCB1 as a Potential Disease Modifier in Cortisol-Producing Adrenal Adenomas.

doi:10.1055/a-2408-0718

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Article

Polymorphism in the Drug Transporter Gene ABCB1 as a Potential Disease Modifier in Cortisol-Producing Adrenal Adenomas.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Nov 2024

Vogel Frederick, Braun Leah, Vetrivel Sharmilee, Zhang Ru, Zopp Stephanie, Oßwald Andrea, Nowak Elisabeth, Schilbach Katharina, Bidlingmaier Martin, Zimmermann Petra, Beuschlein Felix, Hartmann Michaela, Wudy Stefan, Riester Anna, Reincke Martin

Abstract excerpt

INTRODUCTION: Endogenous hypercortisolism presents with variable phenotypes. Etiological factors accounting for the level of hypercortisolism or varying severity of associated comorbidities are lacking. Recently, the adrenal ATP-binding cassette B1 (ABCB1) gene was identified as a modulator of glucocorticoid secretion. OBJECTIVE: To evaluate the effect of ABCB1 polymorphism rs2032582 on steroid metabolome and...

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PMID: 39293469
DOI: 10.1055/a-2408-0718

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