Article
Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency.
American journal of hypertension - 16 Jul 2018
Carvajal Cristian A, Tapia-Castillo Alejandra, Valdivia Carolina P, Allende Fidel, Solari Sandra, Lagos Carlos F, Campino Carmen, Martínez-Aguayo Alejandro, Vecchiola Andrea, Pinochet Constanza, Godoy Claudia, Iturrieta Virginia, Baudrand Rene, Fardella Carlos E
Abstract excerpt
BACKGROUND: Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We investigated if serum cortisol/cortisone (F/E) ratio and cortisone are useful for identifying partial 11βHSD2 deficiency in those heterozygous subjects. METHODS: We studied two...
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