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Article

Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.

Molecular and cellular endocrinology - 1 Dec 2021

Baba Ryuta, Oki Kenji, Gomez-Sanchez Celso E, Otagaki Yu, Itcho Kiyotaka, Kobuke Kazuhiro, Kodama Takaya, Nagano Gaku, Ohno Haruya, Yoneda Masayasu, Hattori Noboru

Abstract excerpt

The intracellular molecular mechanisms underlying the genotype of cortisol-producing adenoma (CPA) have not been fully determined. We analyzed gene expressions in CPA and the human adrenocortical cell line (HAC15 cells) with PRKACA mutation. Clustering analysis using a gene set associated with responses to cAMP revealed the possible differences between PRKACA mutant CPAs and GNAS and CTNNB1 mutant CPAs. The...

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Identifiers

PMID: 34520814
DOI: 10.1016/j.mce.2021.111456
PMCID: PMC8551059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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