Article

Associations of ‘Relative corticosterone deficiency’ with genetic variation in <i>CYP17A1</i> and metabolic syndrome features

2019-05-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Context and objective</h4> Common genetic variants in CYP17A1 associate with higher blood pressure, putatively from impaired 17α-hydroxylase activity and mineralocorticoid excess. However, the same variants protect against obesity and insulin resistance. We tested whether CYP17A1 variants that enhance 17α-hydroxylase activity cause ‘relative corticosterone deficiency’. Since corticosteron...

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Literature Corpus work: e9c12842-1e09-57d3-b5d8-5dd37e551ace
DOI: 10.1101/654269

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