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Unraveling the brain-joint axis: genetic, transcriptomic, and cohort insights from neuroticism to osteoarthritis.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2025

Zhang Jingwei, Li Yingjie, Li Yongzhen, Liu Hongwei

Abstract excerpt

The causal relationships between neuroticism and osteoarthritis (OA) were inconclusive in observational studies. We conducted bidirectional two-sample Mendelian randomization (MR) and transcriptome-wide association studies to determine the associations and the underlying transcriptomic basis. The summary-level genome-wide association study data for any site OA, knee OA, erosive hand OA, and hip OA were mainly...

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PMID: 40080206
DOI: 10.1007/s00335-025-10112-4

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