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Article

Signaling to Myosin Regulatory Light Chain in Sarcomeres

22 Jan 2011

Abstract excerpt

Myosin regulatory light chain (RLC) phosphorylation in skeletal and cardiac muscles modulates Ca(2+)-dependent troponin regulation of contraction. RLC is phosphorylated by a dedicated Ca(2+)-dependent myosin light chain kinase in fast skeletal muscle, where biochemical properties of RLC kinase and phosphatase converge to provide a biochemical memory for RLC phosphorylation and post-activation potentiation of...

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PMID: 21257758
DOI: 10.1074/jbc.r110.198697

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