Article
Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.
Molecular immunology - 1 Feb 2015
Arduin E, Arora S, Bamert P R, Kuiper T, Popp S, Geisse S, Grau R, Calzascia T, Zenke G, Kovarik J
Abstract excerpt
The effects of the Fc silencing mutations such as leucine (L) to alanine (A) substitution at the position 234 and 235 (LALA) and the alanine (A) to asparagine (N) substitution at position 297 (N297A) are well investigated for human IgG. However, the effects of the same two silencing Fc mutations in a mouse IgG backbone are not yet well investigated in respect to binding to mouse Fc gamma receptors (FcγRs),...
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