Discovery metabolomics and genetic analysis reveal lipid pathway alterations associated with malignant phenotype acquisition in pleomorphic adenoma and a novel NTF3::ITPR2 fusion in carcinoma ex pleomorphic adenoma.

doi:10.1007/s00428-025-04242-y

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Discovery metabolomics and genetic analysis reveal lipid pathway alterations associated with malignant phenotype acquisition in pleomorphic adenoma and a novel NTF3::ITPR2 fusion in carcinoma ex pleomorphic adenoma.

Virchows Archiv : an international journal of pathology - 1 Jun 2026

de Lima-Souza Reydson Alcides, de Carvalho Kimura Talita, Scarini João Figueira, Lavareze Luccas, Maciel Tayná Figueiredo, Damas Ingrid Iara, Hara Laura Wachter, de Sousa Mesquita Alessandra, Simionato Ana Valéria Colnaghi, Martínek Petr, Michal Michal, Kowalski Luiz Paulo, Egal Erika Said Abu, Altemani Albina, Skálová Alena, Mariano Fernanda Viviane

Abstract excerpt

Pleomorphic adenoma (PA) is the most common salivary gland tumor. Although it is benign, PA may recur, metastasize, and undergo malignant transformation into carcinoma ex pleomorphic adenoma (CXPA). The mechanisms underlying this transformation are unclear, but it is believed that they involve the accumulation of molecular alterations. This study aimed to analyze the metabolomic profile associated with the...

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PMID: 41081890
DOI: 10.1007/s00428-025-04242-y

Genes

ITPR2
NTF3
ARID1A
CHEK1
FOXA1
GATA2
LZTR1
NSD1
PIK3CA
TP53
XPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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