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Article

Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer.

British journal of cancer - 1 Jan 2023

Chen Kuo-Hsing, Hsu Chia-Lang, Su Yu-Li, Yuan Chang-Tsu, Lin Liang-In, Tsai Jia-Huei, Liang Yi-Hsin, Cheng Ann-Lii, Yeh Kun-Huei

Abstract excerpt

BACKGROUND: Prognosis of metastatic BRAF V600E mutant colorectal cancer (CRC) is poor, and the prognostic implications of immune contextures in the tumour microenvironment (TME) for CRC remain elusive. METHODS: We collected the primary tumour specimens and clinicopathological characteristics of patients with de novo metastatic microsatellite-stable BRAF V600E mutant CRC from two medical centres. Gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36319846
DOI: 10.1038/s41416-022-02010-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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