Article
Strong Activation of ID1, ID2, and ID3 Genes Is Coupled with the Formation of Vasculogenic Mimicry Phenotype in Melanoma Cells.
International journal of molecular sciences - 27 Aug 2024
Tchurikov Nickolai A, Vartanian Amalia A, Klushevskaya Elena S, Alembekov Ildar R, Kretova Antonina N, Lukicheva Viktoriya N, Chechetkin Vladimir R, Kravatskaya Galina I, Kosorukov Vyacheslav S, Kravatsky Yuri V
Abstract excerpt
Gene expression patterns are very sensitive to external influences and are reflected in phenotypic changes. It was previously described that transferring melanoma cells from a plastic surface to Matrigel led to formation of de novo vascular networks-vasculogenic mimicry-that are characteristic to a stemness phenotype in aggressive tumors. Up to now there was no detailed data about the gene signature accompanying...
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