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Comparative analysis of methodologies for detecting extrachromosomal circular DNA

24 Oct 2024

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identification, their detection efficiencies have not been systematically assessed. To address this, we evaluate the performance of 7 analysis pipelines using seven simulated datasets, in...

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PMID: 39448595
DOI: 10.1038/s41467-024-53496-8

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