Article
Spatial whole exome sequencing reveals the genetic features of highly-aggressive components in lung adenocarcinoma.
Neoplasia (New York, N.Y.) - 1 Aug 2024
Li Jianfu, Xiong Shan, He Ping, Liang Peng, Li Caichen, Zhong Ran, Cai Xiuyu, Xie Zhanhong, Liu Jun, Cheng Bo, Chen Zhuxing, Liang Hengrui, Lao Shen, Chen Zisheng, Shi Jiang, Li Feng, Feng Yi, Huo Zhenyu, Deng Hongsheng, Yu Ziwen, Wang Haixuan, Zhan Shuting, Xiang Yang, Wang Huiting, Zheng Yongmin, Lin Xiaodong, He Jianxing, Liang Wenhua
Abstract excerpt
In invasive lung adenocarcinoma (LUAD), patients with micropapillary (MIP) or solid (SOL) components had a significantly poorer prognosis than those with only lepidic (LEP), acinar (ACI) or papillary (PAP) components. It is interesting to explore the genetic features of different histologic subtypes, especially the highly aggressive components. Based on a cohort of 5,933 patients, this study observed that in...
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