Article

The histologic phenotype of lung cancers may be driven by transcriptomic features rather than genomic characteristics

2021-01-04

Abstract excerpt

Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are largely unknown. We conducted whole-exome sequencing(WES) and microarray profiling on 19 micro-dissected tumor regions of different histologic subtypes from 9 patients with lung cancers of mixed histology. A median of 68.9% of point mutations and 83% of copy nu...

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Literature Corpus work: 56884c6a-a6a9-55c1-bfb2-6b87d567f4de
DOI: 10.1101/2021.01.01.425056

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