Article
The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics.
Nature communications - 6 Dec 2021
Tang Ming, Abbas Hussein A, Negrao Marcelo V, Ramineni Maheshwari, Hu Xin, Hubert Shawna Marie, Fujimoto Junya, Reuben Alexandre, Varghese Susan, Zhang Jianhua, Li Jun, Chow Chi-Wan, Mao Xizeng, Song Xingzhi, Lee Won-Chul, Wu Jia, Little Latasha, Gumbs Curtis, Behrens Carmen, Moran Cesar, Weissferdt Annikka, Lee J Jack, Sepesi Boris, Swisher Stephen, Cheng Chao, Kurie Jonathan, Gibbons Don, Heymach John V, Wistuba Ignacio I, Futreal P Andrew, Kalhor Neda, Zhang Jianjun
Abstract excerpt
Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are largely unknown. We conduct whole-exome sequencing and microarray profiling on 19 micro-dissected tumor regions of different histologic subtypes from 9 patients with lung cancers of mixed histology. A median of 68.9% of point mutations and 83% of copy number...
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