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Mutational spectrum of breast cancer by shallow whole-genome sequencing of cfDNA and tumor gene panel analysis.

PloS one - 1 Jan 2024

Ambriz-Barrera Fernando, Rojas-Jiménez Ernesto, Díaz-Velásquez Clara Estela, De-La-Cruz-Montoya Aldo Hugo, Martínez-Gregorio Héctor, Ruiz-De-La-Cruz Miguel, Huertas Antonio, Montealegre Ana Lorena, Castro-Rojas Carlos, Acosta Gabriela, Vaca-Paniagua Felipe, Perdomo Sandra

Abstract excerpt

Breast cancer (BC) has different molecular subgroups related to different risks and treatments. Tumor biopsies for BC detection are invasive and may not reflect tumor heterogeneity. Liquid biopsies have become relevant because they might overcome these limitations. We rationalize that liquid cfDNA biopsies through shallow whole genome sequencing (sWGS) could improve the detection of tumor alterations,...

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Aged
Biomarkers, Tumor
Breast Neoplasms
Cell-Free Nucleic Acids
Circulating Tumor DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Copy Number Variations

Whole Genome Sequencing

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Identifiers

PMID: 39264897
DOI: 10.1371/journal.pone.0308176
PMCID: PMC11392417

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