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Targeting the leukemia–stroma interaction in acute myeloid leukemia: rationale and latest evidence

10 Dec 2015

Abstract excerpt

The concept of 'niche' has become a focus of attention in hematologic malignancies including acute myeloid leukemia (AML). Similar to normal hematopoietic stem cells, AML cells interact both anatomically and functionally with the stroma within the marrow microenvironment. These interactions have a critical role in the development, progression, and relapse of AML. Chemotherapy resistance is another feature that is...

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PMID: 26834953
DOI: 10.1177/2040620715619307

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