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Macrophage migration inhibitory factor in the pathogenesis of leukemia (Review)

6 Jul 2021

Abstract excerpt

Leukemia is a group of malignant diseases of clonal hematopoietic stem‑progenitor cells and its pathological mechanisms remain to be elucidated. Genetic and epigenetic abnormalities, as well as microenvironmental factors, including cytokines, serve critical roles in leukaemogenesis. Macrophage migration inhibitory factor (MIF) has been presented as one of the key regulators in tumorigenesis, angiogenesis and...

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PMID: 34278453
DOI: 10.3892/ijo.2021.5242

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