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Article

Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2024

Bourrienne Marie-Charlotte, Loyau Stéphane, Faille Dorothée, Gay Juliette, Akhenak Séléna, Farkh Carine, Ollivier Véronique, Solonomenjanahary Mialitiana, Dupont Sébastien, Choqueux Christine, Villeval Jean-Luc, Plo Isabelle, Edmond Valérie, Ho-Tin-Noé Benoît, Ajzenberg Nadine, Mazighi Mikaël

Abstract excerpt

BACKGROUND: Myeloproliferative neoplasms (MPNs) are characterized by a high rate of thrombotic complications that contribute to morbidity and mortality. MPN-related thrombogenesis is assumed to be multifactorial, involving both procoagulant and proinflammatory processes. Whether impaired fibrinolysis also participates in the prothrombotic phenotype of MPN has been poorly investigated. OBJECTIVES: We determined...

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Identifiers

PMID: 39260744
DOI: 10.1016/j.jtha.2024.07.031

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CALR

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