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Article

Increased levels of NETosis in myeloproliferative neoplasms are not linked to thrombotic events.

Blood advances - 28 Sept 2021

Schmidt Stefan, Daniliants Dimitri, Hiller Elisabeth, Gunsilius Eberhard, Wolf Dominik, Feistritzer Clemens

Abstract excerpt

Morbidity and mortality of Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are mainly determined by thromboembolic complications. Thrombus formation is facilitated by a neutrophil-specific form of cell death linked to neutrophil extracellular trap (NET) formation (NETosis). Preclinical and clinical data suggested a potential link between NETosis and thrombosis in MPNs. In this study, we aimed...

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Identifiers

PMID: 34464975
DOI: 10.1182/bloodadvances.2020004061
PMCID: PMC8945589

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