Article
Thromboinflammation in ischemic cerebrovascular patients with the JAK2V617F mutation.
Thrombosis research - 1 Jan 2025
Kristiansen Marie Hvelplund, Larsen Morten Kranker, Massarenti Laura, Skov Vibe, Kjær Lasse, Enevold Christian, Ostrowski Sisse Rye, Nielsen Claus Henrik, Hasselbalch Hans Carl, Wienecke Troels
Abstract excerpt
BACKGROUND: The JAK2V617F mutation is a driver of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) and is also implicated in cardiovascular diseases. Thrombosis in MPN involves JAK2V617F-associated platelet activation and endothelial dysfunction, all potentially influenced by chronic inflammation. Whether the mutation affects thromboinflammatory markers similarly in non-MPN patients remains...
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