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Article

HOXD12 defines an age-related aggressive subtype of oligodendroglioma.

Acta neuropathologica - 11 Sept 2024

Nuechterlein Nicholas, Cimino Sadie, Shelbourn Allison, Ha Vinny, Arora Sonali, Rajan Sharika, Shapiro Linda G, Holland Eric C, Aldape Kenneth, McGranahan Tresa, Gilbert Mark R, Cimino Patrick J

Abstract excerpt

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted has highly variable outcomes that are strongly influenced by patient age. The distribution of oligodendroglioma age is non-Gaussian and reportedly bimodal, which motivated our investigation of age-associated molecular alterations that may drive poorer outcomes. We found that elevated HOXD12 expression was associated with both older patient age and shorter...

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Identifiers

PMID: 39259414
DOI: 10.1007/s00401-024-02802-1
PMCID: PMC11390787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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