Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

11 Mar 2019

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to interferon and immune responses
Share to Systemic Lupus Erythematosus Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30872080
DOI: 10.1016/j.jaut.2019.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse modelPMID 30872080Read ↗

cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient miceSemantic proximity Read ↗

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesSemantic proximity Read ↗

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like AutoimmunitySemantic proximity Read ↗

Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Goutières syndrome.Semantic proximity Read ↗

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.Semantic proximity Read ↗

Systemic involvement in TREX1-associated familial chilblain lupus.Semantic proximity Read ↗

Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune DiseaseSemantic proximity Read ↗

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent MannerSemantic proximity Read ↗

Epigenetically Altered T Cells Contribute to Lupus FlaresSemantic proximity Read ↗

Heterozygous TREX1 p.Asp18Asn mutation can cause variable neurological symptoms in a family with Aicardi-Goutieres syndrome/familial chilblain lupus.Semantic proximity Read ↗

Clinical heterogeneity among a three-generation Japanese family with D18N TREX1 mutation for Aicardi-Goutières syndrome / familial chilblain lupusSemantic proximity Read ↗

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.