Article
The genetics of Alzheimer disease: back to the future.
Neuron - 21 Oct 2010
Bertram Lars, Lill Christina M, Tanzi Rudolph E
Abstract excerpt
Three decades of genetic research in Alzheimer disease (AD) have substantially broadened our understanding of the pathogenetic mechanisms leading to neurodegeneration and dementia. Positional cloning led to the identification of rare, disease-causing mutations in APP, PSEN1, and PSEN2 causing early-onset familial AD, followed by the discovery of APOE as the single most important risk factor for late-onset AD....
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mutation
- Presenilin-1
- Presenilin-2