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<i>Trans</i> -pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci

27 Jul 2016

Abstract excerpt

OBJECTIVE: Given evidence from genetic studies, we hypothesized that there may be a shared component to the role of myeloid function in Parkinson and Alzheimer disease (PD and AD) and assessed whether PD susceptibility variants influenced protein expression of well-established AD-associated myeloid genes in human monocytes. METHODS: We repurposed data in which AD-related myeloid proteins CD33, TREM1, TREM2,...

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PMID: 27504496
DOI: 10.1212/nxg.0000000000000090

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