Article
A chimera analysis of prestin knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Sept 2009
Cheatham Mary Ann, Low-Zeddies Sharon, Naik Khurram, Edge Roxanne, Zheng Jing, Anderson Charles T, Dallos Peter
Abstract excerpt
A chimera is a genetic composite containing a unique mix of cells derived from more than one zygote. This mouse model allows one to learn how cells of contrasting genotype functionally interact in vivo. Here, we investigate the effect that different proportions of prestin-containing outer hair cells (OHC) have on cochlear amplification. To address this issue, we developed a prestin chimeric mouse in which both...
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