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Article

A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012

Lukashkin Andrei N, Legan P Kevin, Weddell Thomas D, Lukashkina Victoria A, Goodyear Richard J, Welstead Lindsey J, Petit Christine, Russell Ian J, Richardson Guy P

Abstract excerpt

The gene causative for the human nonsyndromic recessive form of deafness DFNB22 encodes otoancorin, a 120-kDa inner ear-specific protein that is expressed on the surface of the spiral limbus in the cochlea. Gene targeting in ES cells was used to create an EGFP knock-in, otoancorin KO (Otoa(EGFP/EGFP)) mouse. In the Otoa(EGFP/EGFP) mouse, the tectorial membrane (TM), a ribbon-like strip of ECM that is normally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23129639
DOI: 10.1073/pnas.1210159109
PMCID: PMC3511093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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