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Article

Transcriptomics and phenotypic analysis of OTOF gene knockdown in zebrafish mediated by CRISPR/Cas9.

Gene expression patterns : GEP - 1 Jun 2025

Bai Xuejing, Xu Wenbo, Zhu Ying, Luo Beibei, Ye Dan

Abstract excerpt

Deafness is a common genetic disorder, where mutations,in the OTOF gene can disrupt the normal functionof the Otoferlin protein, leading to impaired neurotransmitter release in the inner ear and subsequent deafness. Despite the complexity of the pathogenic mechanism,it is not fully understood. Zebrafish are an excellent model for studying genetically-induced deafness,but there have been no previous reports on the...

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Identifiers

PMID: 40250544
DOI: 10.1016/j.gep.2025.119394

Genes

OTOF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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