Article
Differences in histological features and PD-L1 expression between sporadic microsatellite instability and Lynch-syndrome-associated disease in Japanese patients with colorectal cancer.
International journal of clinical oncology - 1 Jun 2018
Yamada Rin, Yamaguchi Tatsuro, Iijima Takeru, Wakaume Rika, Takao Misato, Koizumi Koichi, Hishima Tsunekazu, Horiguchi Shin-Ichiro
Abstract excerpt
BACKGROUND: The field of immunotherapy has recently focused on cancers with microsatellite instability (MSI). These cancers include both Lynch-syndrome-associated tumors, which are caused by mismatch repair (MMR) germline mutations, and sporadic MSI tumors, which are mainly attributed to MLH1 promoter methylation. The present study aimed to clarify differences in the histological and PD-L1 expression profiles...
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