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Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors

1 Oct 2021

Abstract excerpt

Introduction Mismatch repair (MMR)-deficient and DNA polymerase epsilon (POLE)-mutated tumors exhibit a high tumor mutation burden (TMB) and have been proven to be associated with good responses to immune checkpoint inhibitor treatments. However, the relationship between mutational characteristics of MMR-deficient and POLE-mutated tumors and the spatial architecture of tumor-infiltrating lymphocytes (TILs) has...

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PMID: 34607897
DOI: 10.1136/jitc-2021-002797

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