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Article

Tviblindi algorithm identifies branching developmental trajectories of human B-cell development and describes abnormalities in RAG-1 and WAS patients.

European journal of immunology - 1 Dec 2024

Bakardjieva Marina, Pelák Ondřej, Wentink Marjolein, Glier Hana, Novák David, Stančíková Jitka, Kužílková Daniela, Mejstříková Ester, Janowska Iga, Rizzi Marta, van der Burg Mirjam, Stuchlý Jan, Kalina Tomáš

Abstract excerpt

Detailed knowledge of human B-cell development is crucial for the proper interpretation of inborn errors of immunity and malignant diseases. It is of interest to understand the kinetics of protein expression changes during development, but also to properly interpret the major and possibly alternative developmental trajectories. We have investigated human samples from healthy individuals with the aim of describing...

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Identifiers

PMID: 39235410
DOI: 10.1002/eji.202451004
PMCID: PMC11628918

Genes

CXCR4
CXCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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