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Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling

1 Sept 2007

Abstract excerpt

We have characterized several stages of normal human B cell development in adult bone marrow by gene expression profiling of hemopoietic stem cells, early B (E-B), pro-B, pre-B, and immature B cells, using RNA amplification and Lymphochip cDNA microarrays (n = 6). Hierarchical clustering of 758 differentially expressed genes clearly separated the five populations. We used gene sets to investigate the functional...

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PMID: 17785802
DOI: 10.4049/jimmunol.179.6.3662

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