Article
Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations.
Journal of gastroenterology - 1 Nov 2024
Yamauchi Kozue, Maekawa Shinya, Osawa Leona, Komiyama Yasuyuki, Nakakuki Natsuko, Takada Hitomi, Muraoka Masaru, Suzuki Yuichiro, Sato Mitsuaki, Takano Shinichi, Enomoto Nobuyuki
Abstract excerpt
BACKGROUND: Defective hepatitis C virus (HCV) genomes with deletion of the envelope region have been occasionally reported by short-read sequencing analyses. However, the clinical and virological details of such deletion HCV have not been fully elucidated. METHODS: We developed a highly accurate single-molecule sequencing system for full-length HCV genes by combining the third-generation nanopore sequencing with...
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