Article
Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.
PloS one - 1 Jan 2015
Cheroni Cristina, Donnici Lorena, Aghemo Alessio, Balistreri Francesca, Bianco Annalisa, Zanoni Valeria, Pagani Massimiliano, Soffredini Roberta, D'Ambrosio Roberta, Rumi Maria Grazia, Colombo Massimo, Abrignani Sergio, Neddermann Petra, De Francesco Raffaele
Abstract excerpt
Hepatitis C virus (HCV) variants characterized by genomic deletions in the structural protein region have been sporadically detected in liver and serum of hepatitis C patients. These defective genomes are capable of autonomous RNA replication and are packaged into infectious viral particles in cells co-infected with the wild-type virus. The prevalence of such forms in the chronically HCV-infected population and...
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