Article
Characterization of hepatitis C virus deletion mutants circulating in chronically infected patients.
Journal of virology - 1 Nov 2007
Noppornpanth Suwanna, Smits Saskia L, Lien Truong Xuan, Poovorawan Yong, Osterhaus Albert D M E, Haagmans Bart L
Abstract excerpt
Hepatitis C virus (HCV) has a linear positive-stranded RNA genome of approximately 9,600 nucleotides in length and displays a high level of sequence diversity caused by high mutation rates and recombination. However, when we performed long distance reverse transcription-PCRs on HCV RNA isolated from serum of chronic HCV patients, not only full-length HCV genomes but also HCV RNAs which varied in size from 7,600...
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