Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of novel HCV deletion mutants in chronic hepatitis C patients.

Antiviral therapy - 1 Jan 2012

Kohno Tomohiko, Tsuge Masataka, Hayes C Nelson, Hatakeyama Tsuyoshi, Ohnishi Mayu, Abe Hiromi, Miki Daiki, Hiraga Nobuhiko, Imamura Michio, Takahashi Shoichi, Ochi Hidenori, Tanaka Shinji, Chayama Kazuaki

Abstract excerpt

BACKGROUND: The HCV genome consists of a positive 9.6 kb single-strand of RNA. Nucleotide substitutions in the HCV genome are common and a 2 kb deletion has been reported. METHODS: A total of 117 chronic hepatitis C (CHC) patients who were treated with pegylated interferon plus ribavirin combination therapy were enrolled in this study. Total RNA was extracted from the patients' sera and reverse transcription and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Order

Share to Genome, Viral

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Viral Load

Source

Identifiers

PMID: 22837441
DOI: 10.3851/IMP2265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of novel HCV deletion mutants in chronic hepatitis C patients.PMID 22837441Read ↗

Characterization of hepatitis C virus deletion mutants circulating in chronically infected patients.Semantic proximity Read ↗

Single-molecule sequencing of the whole HCV genome revealed envelope deletions in decompensated cirrhosis associated with NS2 and NS5A mutations.Semantic proximity Read ↗

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.Semantic proximity Read ↗

Discovery of significant variants containing large deletions in the 5'UTR of human hepatitis C virus (HCV).Semantic proximity Read ↗

Molecular virology of hepatitis C virus.Semantic proximity Read ↗

Genome-Wide Mutagenesis of Hepatitis C Virus Reveals Ability of Genome To Overcome Detrimental Mutations.Semantic proximity Read ↗

High-Resolution Functional Profiling of Hepatitis C Virus GenomeSemantic proximity Read ↗

A Comprehensive Functional Map of the Hepatitis C Virus Genome Provides a Resource for Probing Viral ProteinsSemantic proximity Read ↗

Sequence variability of the 5' UTR in isolates of hepatitis C virus in China.Semantic proximity Read ↗

Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection.Semantic proximity Read ↗

Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers.Semantic proximity Read ↗

Sequence analysis of the 5' noncoding region of hepatitis C virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.