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Article

Improved hepatitis delta virus genome characterization by single molecule full-length genome sequencing combined with VIRiONT pipeline.

Journal of medical virology - 1 Mar 2023

Charre Caroline, Regue Hadrien, Dény Paul, Josset Laurence, Chemin Isabelle, Zoulim Fabien, Scholtes Caroline

Abstract excerpt

Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection confers a greater risk for accelerated liver disease progression. Full-length characterization of HDV genome is necessary to understand pathogenesis and treatment response. However, owing to its high variability and tight structure, sequencing approaches remain challenging. Herein, we present a workflow to amplify, sequence, and analyze the whole HDV...

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PMID: 36879535
DOI: 10.1002/jmv.28634

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