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Article

Association between interleukin-12 p40 subunit and risk of primary Sjögren's disease: a Mendelian randomization study.

Rheumatology (Oxford, England) - 1 Apr 2025

Zuckerman Benjamin P, Yang Zijing, Warwick Alasdair, Wincup Chris, Russell Mark D, Galloway James B, Zhao Sizheng Steven

Abstract excerpt

OBJECTIVES: IL-12 signalling was proposed in the immunopathogenesis of primary Sjögren's disease. The efficacy of therapies targeting this pathway is currently unclear. Herein, we investigated the associations between circulating proteins involved in the IL-12 and IL-23 signalling pathways on primary Sjögren's disease using Mendelian randomization. METHODS: We selected single nucleotide polymorphisms from protein...

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Topics

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Share to Genetic Predisposition to Disease
Share to Interleukin-12 Subunit p40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Receptors, Interleukin

Share to Receptors, Interleukin-12

Share to Sjogren's Syndrome

Source

Identifiers

PMID: 39222420
DOI: 10.1093/rheumatology/keae475

Genes

IL12A
IL12B
IL23R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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