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Article

The causal effect of interleukin-17 on the risk of psoriatic arthritis: a Mendelian randomization study.

Rheumatology (Oxford, England) - 6 Apr 2021

Wu Dongze, Wong Priscilla, Lam Steven H M, Li Edmund K, Qin Ling, Tam Lai-Shan, Gu Jieruo

Abstract excerpt

OBJECTIVE: To determine causal associations between genetically predicted TNF-α, IL-12p70 and IL-17 levels and risk of PsA. METHODS: The publicly available summary-level findings from genome-wide association studies (GWAS) was used to identify loci influencing normal physiological concentrations of TNF-α, IL-12p70 and IL-17 (n = 8293) among healthy individuals as exposure and a GWAS for PsA from the UK Biobank...

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PMID: 33188428
DOI: 10.1093/rheumatology/keaa629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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