Unusual mutation clusters provide insight into class I gene conversion mechanisms.

doi:10.1128/mcb.13.7.4374-4381.1993

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Article

Unusual mutation clusters provide insight into class I gene conversion mechanisms.

Molecular and cellular biology - 1 Jul 1993

Pease L R, Horton R M, Pullen J K, Yun T J

Abstract excerpt

Genetic diversity among the K and D alleles of the mouse major histocompatibility complex is generated by gene conversion among members of the class I multigene family. The majority of known class I mutants contain clusters of nucleotide changes that can be traced to linked family members. Howeve...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
DNA
Gene Conversion
Genes, MHC Class I
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Multigene Family
Mutation

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