Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice.

Journal of virology - 22 Oct 2024

Yang Yuying, Xu Chengzhi, Zhang Naixin, Wan Yunfei, Wu Yunpu, Meng Fei, Chen Yan, Yang Huanliang, Liu Liling, Qiao Chuanling, Chen Hualan

Abstract excerpt

Reassortant Eurasian avian-like H1N1 (rEA H1N1) viruses carrying the internal genes of H1N1/2009 virus have been circulating in pigs for more than 10 years and have caused sporadic human infections. The enhanced virulence phenotype of the rEA H1N1 viruses highlights potential risks to public health. However, the molecular mechanism underlying the viral pathogenicity of the currently circulating rEA H1N1 viruses...

Topics

Join the communities discussing this publication.

Amino Acids
Dogs
Influenza A Virus, H1N1 Subtype
Madin Darby Canine Kidney Cells
Orthomyxoviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reassortant Viruses

RNA-Dependent RNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 39212447
DOI: 10.1128/jvi.01293-24
PMCID: PMC11495010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice.PMID 39212447Read ↗

A Eurasian avian-like H1N1 swine influenza reassortant virus became pathogenic and highly transmissible due to mutations in its PA gene.Semantic proximity Read ↗

The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza VirusesSemantic proximity Read ↗

Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice.Semantic proximity Read ↗

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in miceSemantic proximity Read ↗

A Combination of HA and PA Mutations Enhances Virulence in a Mouse-Adapted H6N6 Influenza A VirusSemantic proximity Read ↗

Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza virusesSemantic proximity Read ↗

The substitution of T271A in PB2 protein could enhance the infectivity and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses in miceSemantic proximity Read ↗

Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.Semantic proximity Read ↗

Adaptive Amino Acid Substitutions Enhance the Virulence of a Novel Swine-Origin Canine H1N1 Influenza Virus in MiceSemantic proximity Read ↗

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.Semantic proximity Read ↗

A Single Amino Acid at Position 431 of the PB2 Protein Determines the Virulence of H1N1 Swine Influenza Viruses in Mice.Semantic proximity Read ↗

Mutations in PB2 and HA are crucial for the increased virulence and transmissibility of H1N1 swine influenza virus in mammalian models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.