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ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells

21 Sept 2018

Abstract excerpt

BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation of viral protein in the ER by viral infection. Then, unfolded protein response (UPR) is activated to alleviate the stress. Zika virus (ZIKV) is a mosquito-borne...

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PMID: 30241539
DOI: 10.1186/s12974-018-1311-5

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