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A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection

29 May 2019

Abstract excerpt

Zika virus (ZIKV) is an emerging vector-borne pathogen causing a febrile disease. ZIKV infection might also trigger Guillain-Barré syndrome, neuropathy, and myelitis. Vertical transmission of ZIKV can cause fetus demise, stillbirth, or severe congenital abnormalities and neurological complications. There is no vaccine or specific antiviral treatment against ZIKV. We used a genome-wide CRISPR activation screen,...

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PMID: 31142663
DOI: 10.1128/jvi.00211-19

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