Article

CHOP Pro-Apoptotic Transcriptional Program in Response to ER Stress Is Hacked by Zika Virus

2021-04-03

Abstract excerpt

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus considered as a threat to human health due to large epidemics and serious clinical outcomes such as microcephaly in new-borns. Like all flaviviruses, ZIKV relies on the cellular machinery to complete its viral cycle, with the endoplasmic reticulum (ER) being the critical site of viral replication factories. The sudden high protein load in the ER induces an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 950717f2-1cb5-5c89-986c-fdf2a4236597
DOI: 10.3390/ijms22073750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CHOP Pro-Apoptotic Transcriptional Program in Response to ER Stress Is Hacked by Zika VirusDOI 10.3390/ijms22073750Read

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cellsSemantic proximity Read

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial InfectionSemantic proximity Read

Complementary Mechanisms Potentially Involved in the Pathology of Zika VirusSemantic proximity Read

Apoptosis during ZIKA Virus Infection: Too Soon or Too Late?Semantic proximity Read

Endoplasmic reticulum: a focal point of Zika virus infectionSemantic proximity Read

New insights into the roles of CHOP-induced apoptosis in ER stressSemantic proximity Read

Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virusSemantic proximity Read

Zika Virus Neuropathogenesis—Research and UnderstandingSemantic proximity Read

Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress ResponseSemantic proximity Read

Coronavirus infection, ER stress, apoptosis and innate immunitySemantic proximity Read

IRE1α Promotes Zika Virus Infection via XBP1Semantic proximity Read

A functional interaction between GRP78 and Zika virus E proteinSemantic proximity Read