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Article

Performance of a Novel Plasmodium falciparum Rapid Diagnostic Test in Areas of Widespread hrp2/3 Gene Deletion.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 4 Feb 2026

Mandefro Aynalem, Ding Xavier C, Farge Jocelyn, Alemayehu Gezahegn Solomon, Tadele Geletta, Mekonen Bacha, Gebrehiwot Yirgalem, Berhe Nega, Erko Berhanu, Slater Hannah C, Bizilj Greg T, Barney Rebecca, Golden Allison, Domingo Gonzalo J, Golassa Lemu

Abstract excerpt

BACKGROUND: Rapid diagnostic tests (RDTs) have improved malaria diagnosis; however, the emergence of hrp2/3 gene deletions threatens the reliability of HRP2-based RDTs. This study evaluated the diagnostic performance of a novel RDT detecting both HRP2 and PfLDH in a single test line. METHOD: A cross-sectional study was conducted at two health centers in Ethiopia, recruiting 1004 study participants. Blood samples...

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PMID: 40274531
DOI: 10.1093/cid/ciaf212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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