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Article

Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.

Nature communications - 29 Aug 2024

Bell Richard D, Brendel Matthew, Konnaris Maxwell A, Xiang Justin, Otero Miguel, Fontana Mark A, Bai Zilong, Krenitsky Daria M, Meednu Nida, Rangel-Moreno Javier, Scheel-Toellner Dagmar, Carr Hayley, Nayar Saba, McMurray Jack, DiCarlo Edward, Anolik Jennifer H, Donlin Laura T, Orange Dana E, Kenney H Mark, Schwarz Edward M, Filer Andrew, Ivashkiv Lionel B, Wang Fei

Abstract excerpt

Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenotypes based on cellular composition (pauci-immune, diffuse and lymphoid), suggesting that distinct etiologies warrant specific targeted therapy which motivates a need for cost...

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Identifiers

PMID: 39209814
DOI: 10.1038/s41467-024-51012-6
PMCID: PMC11362542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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