Article
Darier's disease: a calcium-signaling perspective.
Cellular and molecular life sciences : CMLS - 1 Jan 2008
Pani B, Singh B B
Abstract excerpt
Ca(2+) influx evoked across the plasma membrane upon internal store depletion is essential for a myriad of cellular functions including gene expression, cell proliferation, differentiation and even apoptosis. Darier's disease (DD), an autosomal dominant inherited disorder of the skin, arising due to mutations in the isoform 2 of the sarco (endo) plasmic reticulum Ca(2+) ATPase (SERCA2), exemplifies an anomaly of...
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