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Article

A Rapid Molecular Detection Tool for Toxigenic M1UK Streptococcus pyogenes.

The Journal of infectious diseases - 20 Feb 2025

Brouwer Stephan, Das Swairindhree, Hayes Andrew J, Bertolla Olivia M, Davies Mark R, Walker Mark J, Whiley David M, Irwin Adam D, Tickner Jacob A

Abstract excerpt

BACKGROUND: The gradual replacement of the Streptococcus pyogenes M1global genotype by a newly emergent M1UK variant is a global public health threat warranting increased surveillance. M1UK differs from progenitor M1global genotype by 27 single-nucleotide polymorphisms and is characterized by increased speA superantigen expression in vitro. METHODS: An allele-specific real-time polymerase chain reaction assay was...

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Antigens, Bacterial
Bacterial Outer Membrane Proteins
Exotoxins
Molecular Diagnostic Techniques
Queensland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptococcal Infections

Streptococcus pyogenes

Whole Genome Sequencing

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Identifiers

PMID: 39206960
DOI: 10.1093/infdis/jiae437
PMCID: PMC11841628

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