Article
Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.
Journal of the American Heart Association - 3 Sept 2024
Young William J, van der Most Peter J, Bartz Traci M, Bos Maxime M, Biino Ginevra, Duong ThuyVy, Foco Luisa, Lominchar Jesus T, Müller-Nurasyid Martina, Nardone Giuseppe Giovanni, Pecori Alessandro, Ramirez Julia, Repetto Linda, Schramm Katharina, Shen Xia, van Duijvenboden Stefan, van Heemst Diana, Weiss Stefan, Yao Jie, Benjamins Jan-Walter, Alonso Alvaro, Spedicati Beatrice, Biggs Mary L, Brody Jennifer A, Dörr Marcus, Fuchsberger Christian, Gögele Martin, Guo Xiuqing, Ikram M Arfan, Jukema J Wouter, Kääb Stefan, Kanters Jørgen K, Lin Henry J, Linneberg Allan, Nauck Matthias, Nolte Ilja M, Pianigiani Giulia, Santin Aurora, Soliman Elsayed Z, Tesolin Paola, Vaccargiu Simona, Waldenberger Melanie, van der Harst Pim, Verweij Niek, Arking Dan E, Concas Maria Pina, De Grandi Alessandro, Girotto Giorgia, Grarup Niels, Kavousi Maryam, Mook-Kanamori Dennis O, Navarro Pau, Orini Michele, Padmanabhan Sandosh, Pattaro Cristian, Peters Annette, Pirastu Mario, Pramstaller Peter P, Heckbert Susan R, Sinner Mortiz, Snieder Harold, Völker Uwe, Wilson James F, Gauderman W James, Lambiase Pier D, Sotoodehnia Nona, Tinker Andrew, Warren Helen R, Noordam Raymond, Munroe Patricia B
Abstract excerpt
BACKGROUND: Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome-wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained. Previous work supports a causal effect of lower serum calcium concentrations on longer ventricular repolarization time. We hypothesized calcium interactions with QT...
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