Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line.

doi:10.1038/314330a0

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Article

Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line.

Nature - 1 Jan 2000

Rusconi S, Köhler G

Abstract excerpt

Two genes that code for a hapten-specific immunoglobulin M (IgM) have been introduced into the mouse germ line. The transgenic antibody represents 10-50% of the serum IgM and is expressed on the membrane of B cells. B-cell hybridoma lines show that a negative feedback inhibition of mu and kappa t...

Topics

Alleles
Animals
Base Sequence
DNA, Recombinant
Gene Expression Regulation
Genes
Hybridomas
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Immunoglobulin kappa-Chains
Immunoglobulin mu-Chains
Mice
Plasmids
RNA, Messenger
Recombination, Genetic

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